Min Cai, Yingbo Zhu, Mary Regis Shanley, Carole Morel, Stacy M Ku, Hongxing Zhang, Yuan Shen, Allyson K Friedman, Ming-Hu Han. HCN channel inhibitor induces ketamine-like rapid and sustained antidepressant effects in chronic social defeat stress model. Neurobiology of Stress, 2023, 26, 100565.

Yuka Miura, Mary Regis Shanley, Ashley Urbaez and Allyson K. Friedman, 2023, Electrophysiologically distinct bed nucleus of the stria terminalis projections to the ventral tegmental area in mice, Front. Neural Circuits, 16, 1081099. https://doi.org/10.3389/fncir.2022.108109.

M. Regis Shanley, Yuka Miura, Christopher A. Guevara, Amanda Onoichenco, Rufina Kore, Emine Ustundag, Rania Darwish, Lauren Renzoni, Ashley Urbaez, Ella Blicker, Alec Seidenberg, Teresa A. Milner and Allyson K. Friedman, 2022, Estrous cycle mediates midbrain neuron excitability altering social behavior upon stress, Journal of Neuroscience 22 December 2022, JN-RM-1504-22

Carole Morel, Sarah Montgomery, Long Li , Stacy Ku , Barbara Juarez , Romain Durand-de Cuttoli , Nikos Tzavaras, Meghan Flanigan, Min Cai, Jessica Walsh, Scott Russo, Eric Nestler, Erin Calipari, Allyson K. Friedman, Ming-Hu Han. Midbrain projections to the basolateral amygdala encode anxiety- but not depression-like behavior. Nature Communications. 13, 1532 (2022). https://doi.org/10.1038/s41467-022-29155-1.

Allyson K. Friedman. New Insights into the role of ventral hippocampal-nucleus accumbens activity encoding stress vulnerability. (2020), Biological Psychiatry 88 (11), 812-814.

Mitra Heshmati, Daniel J Christoffel, Katherine LeClair, Flurin Cathomas, Sam A Golden, Hossein Aleyasin, Gustavo Turecki, Allyson K Friedman, Ming-Hu Han, Caroline Menard, Scott J Russo. (2020) Depression and social defeat stress are associated with inhibitory synaptic changes in the nucleus accumbens. Journal of Neuroscience. 40 (32), 6228-6233.

Glatigny M, Moriceau S, Rivagorda M, Ramos-Brossier M, Nascimbeni AC, Lante F, Shanley MR, Boudarene N, Rousseaud A, Friedman AK, Settembre C, Kuperwasser N, Friedlander G, Buisson A, Morel E, Codogno P, Oury F. (2019) Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline. Current Biology. 2019 Feb 4;29(3):435-448.e8. doi: 10.1016/j.cub.2018.12.021.

Tan A, Costi S, Morris LS, Van Dam NT, Kautz M, Whitton AE, Friedman AK, Collins KA, Ahle G, Chadha N, Do B, Pizzagalli DA, Iosifescu DV, Nestler EJ, Han MH, Murrough JW. (2018) Effects of the KCNQ channel opener ezogabine on functional connectivity of the ventral striatum and clinical symptoms in patients with major depressive disorder. Molecular Psychiatry. 2018 Nov 1. doi: 10.1038/s41380-018-0283-2. PMID: 30385872.

Zhang H, Chaudhury D, Nectow AR, Friedman AK, Zhang S, Juarez B, Liu H, Pfau ML, Aleyasin H, Jiang C, Crumiller M, Calipari ES, Ku SM, Morel C, Tzavaras N, Montgomery SE, He M, Salton SR, Russo SJ, Nestler EJ, Friedman JM, Cao JL, Han MH. (2018) Alpha1 and beta3 adrenergic receptor-mediated mesolimbic homeostatic plasticity confers resilience to social stress in susceptible mice. Biological Psychiatry, 6 Sept 2018. doi. 10.1016/j.biopsych.2018.08.020.

Guzman D, Carreira MB, Friedman AK, Adachi M, Neve RL, Monteggia LM, Han MH, Cowan CW, Self DW. Inactivation of NMDA Receptors in the Ventral Tegmental Area during Cocaine Self-Administration Prevents GluA1 Upregulation but with Paradoxical Increases in Cocaine-Seeking Behavior. J Neurosci. 2018 Jan 17;38(3):575-585. doi: 10.1523/JNEUROSCI.2828-16.2017.

Juarez B, Morel C, Ku SM, Liu Y, Zhang H, Montgomery S, Gregoire H, Ribeiro E, Crumiller M, Roman-Ortiz C, Walsh JJ, Jackson K, Croote DE, Zhu Y, Zhang S, Vendruscolo LF, Edwards S, Roberts A, Hodes GE, Lu Y, Calipari ES, Chaudhury D, Friedman AK and Han MH. Midbrain circuit regulation of individual alcohol drinking behaviors in mice. Nature Communications 2017 Dec 20;8(1):2220. doi: 10.1038/s41467-017-02365-8.

Friedman AK, Juarez B, Ku S, Zhang H, Calizo R, Walsh JJ, Chaudhury D, Zhang S, Hawkins A, Dietz DM, Murrough JW, Ribadeneira M, Wong E, Neve RL and Han MH. (2016) KCNQ channel openers reverse depressive symptoms via an active resilience mechanism. Nature Communications, 2016 May 24. doi:10.1038/ncomms11671.

Christoffel D, Golden S ,Walsh JJ , Heshmati M, Friedman AK, Dey A , Smith M, Pfau M,  Rebusi N , Ables J , Hodes G , Deisseroth K , Tallon-Ibanez I , Malenka R, Han MH and Russo SJ. (2015) Opposing Effects of Cortical and Thalamic Inputs to Ventral Striatum on Social Stress-Induced Adaptations. Nature Neuroscience 2015 Jul;18(7):962-4. doi: 10.1038/nn.4034.

Friedman AK, Weiss KR and Cropper EC. Specificity of repetition priming: The role of chemical coding. (2015) Journal of Neuroscience 2015 Apr 22;35(16):6326-34.

Friedman AK. (2014) Jump-starting natural resilience reverses stress susceptibility. Science. Oct 31;346(6209):555.

Li B, Jie W, Huang L, WeiP, Shuji Li, Luo Z, Friedman AK, Meredith A, Han MH and Gao T. (2014) Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling.  Nature Neuroscience, 22 June 2014. doi: 10.1038/nn.3744.

Koo JW, Lobo MK, Chaudhury D, Lebonte B, Friedman AK, Heller E, Pena C, Han MH, and Nestler EJ.  (2014) Loss of BDNF signaling in D1R expressing NAc neurons enhances morphine reward by reduction of GABA inhibition. Neuropsychopharmacology, 23 May 2014. doi: 10.1038/npp.2014.118.

Friedman AK, Walsh JJ, Juarez B, Ku SM, Chaudhury D, Neve RL, Wang J, Xianting L, Dietz DM, Pan N, Vialou VF, Neve RL, Yue Z and Han MH. (2014) Enhancing Depression Mechanisms in Midbrain Dopamine Neurons Achieves Homeostatic Resilience. Science, 18 April 2014: 313-319.

 Whalley K. Depression: Becoming resilient. Nature Reviews Neuroscience Highlight 15: 353-353, 2014.

Recommended by Faculty of 1000.

Walsh JJ, Friedman AK, Sun H, Heller EA, Ku SM, Juarez B, Burnham VL, Mazei-Robison M, Ferguson D, Golden SA, Koo JW, Chaudhury D, Christoffel DJ, Pomeranz L, Friedman JM, Russo SJ, Nestler EJ, and Han MH. (2014) Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway. Nature Neuroscience, 17(1):27-9, 2014.

Chaudhury D*, Walsh JJ*, Friedman AK, Juarez B, Ku SM, Koo JW, Ferguson D, Tsai HC, Pomeranz L, Christoffel DJ, Nectow AR, Ekstrand M, Domingos A, Mazei-Robison M, Mouzon E, Lobo MK, Neve RL, Russo SJ, Deisseroth K, Nestler EJ, and Han MH. (2013) Phasic firing of ventral tegmental area dopamine neurons promotes rapid induction of depression behaviors in response to social defeat stress. Nature. 493. 532-536. *Co-first author

 Leading Edge Select: Defeating depression in Cell, 152:663, 2013.

 Recommended by Faculty of 1000.

Kurita M, Holloway T, Aintzane GB, Kozlenkov A, Friedman AK, Moreno JL, Heshmati M, Golden SA, Kennedy PJ, Takahashi N, Dietz DM, Mocci G, Gabilondo AM, Hanks J, Umali A, Callado LF, Gallitano AL, Neve RL, Shen L, Buxbaum JD, Han MH, Nestler EJ, Meana J, Russo SJ and Gonzalez-Maeso J. (2012) HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nature Neuroscience, 2012 Sep;15(9):1245-54.

Mazei-Robison MS, Koo JW, Friedman AK, Lansink CS, Robison AJ, Vinish M, Krishnan V, Kim S, Siuta MA, Galli MA, Niswender KD, Appasani R, Horvath MC, Neve RL, Worley PF, Snyder SH, Hurd YL, Cheer JF, Han MH, Russo SJ and Nestler EJ. (2011) Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons. Neuron, 72(6):977-90.

Choi KH, Edwards S, Graham DL, Larson EB, Whisler KN, Simmons D, Friedman AK, Walsh JJ, Rahman Z, Monteggia LM, Eisch AJ, Neve RL, Nestler EJ, Han MH, Self DW.   (2011)   Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine. The Journal of Neuroscience May 25;31 (21):7927-37.

Cao JL, Covington III HE, Friedman AK, Wilkinson MB, Walsh JJ, Cooper DC, Nestler EJ and Han MH. Mesolimbic dopamine neurons in the brain reward circuit mediate susceptibility to social defeat and antidepressant action. (2010) The Journal of Neuroscience, 30:16453-16458.

This Week in The Journal: Social defeat stress increases bursting in dopaminergic neurons in The Journal of Neuroscience 30: i-i∙i, 2010

Lobo MK, Covington III HE, Chaudhury D, Friedman AK, Sun HS, Damez-Werno D, Dietz D, Zaman S, Koo JW, Kennedy PJ, Mouzon E, Mogri M, Neve RL, Deisseroth K, Han MH, and Nestler EJ (2010). Cell Type-Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward. Science. 330 (6002): 385-390.

Friedman AK and Weiss, K R.  Repetition Priming of Motoneuronal Activity in a Small Motor Network: Intercellular and Intracellular Signaling.  (2010) The Journal of Neuroscience. 30(26): 8906-8919.

Friedman AK, Zhurov Y, Ludwar BC, Weiss KR. (2009) Motor Outputs in a Multitasking Network: Relative Contributions of Inputs and Experience-Dependent Network States. Journal of Neurophysiology.  102:3711 3727.

Proekt A, Vilim F S, Alexeeva V, Brezina V, Friedman AK, Jing J, Li L, Zhurov Y, Sweedler JV, and Weiss KR.  (2005)  Identification of a New Neuropeptide Precursor Reveals a Novel Source of Extrinsic Modulation in the Feeding System of Aplysia.  The Journal of Neuroscience. 25: 9637-9648.